The Himalaya, Karakoram and Tibet (HKT) Orogenic system developed as a result of India-Asia collision and is the quintessential collisional orogen. Geoscientific observations can be made in numerous exceptional exposures as well as through geophysical techniques to unravel its structural, tectonic, sedimentary, geomorphic, magmatic and metamorphic evolution. Understanding of the HKT system is crucial to clarify the evolution of ancient and recent orogens. The aim of this session is to stimulate discussions on recent development and hot topics in this exceptional natural laboratory from different perspectives: (1) climate-tectonics interaction; (2) deep crustal processes including HP and HT rocks; (3) models of exhumation and extrusion: what works for the Himalaya (channel flow, critical taper, their combination, or none of them)?; (4) Himalayan backthrusts, backfolds, out-of-sequence deformation; (5) foreland sedimentation and tectonics; (6) improved understanding of the South Tibetan Detachment System and its displacement (a few km or hundreds of km?); (7) the role and timing of the tectono-metamorphic discontinuities; (8) partial melting within this orogen, especially at the Main Central Thrust Zone; (9) geophysical studies to decipher the India-Asia collision.