Short-term earthquake predictions reliable with an advance warning of several hours or days are currently not possible for technical reasons. In the last years major efforts were undertaken to study and understand earthquake precursor signals to establish a robust earthquake prediction science on sound scientific grounds. In addition, unusual animal behaviour, and other bio-anomalies as a precursor phenomenon prior to earthquakes, have been reported previously but they still create problems with monitoring and reliability. Recently, ground breaking advances in solid state physics, combined with other approaches such as satellite technology and radio sounding methods, electromagnetic anomalies, along with some fortuitous observations of pre-seismic biological changes, have enabled a greater understanding of how some of these physical- and bio-anomalies may come about. The session covers both, the interaction and feedback mechanism between the abiotic and biotic environment prior potentially destructive earthquakes, in order to advance the state of earthquake precursors and biology research and encourage alternative prediction methods.