Exploration of the heliosphere and the outer reaches of our solar system by the Voyagers and New Horizons, and near-Earth remote sensing of the Kuiper Belt and exoplanetary systems have all profoundly changed our view of our space in the universe. An Interstellar Probe escaping beyond the solar-system boundaries with new measurements would be crucial to enable the new understanding and discoveries of the global heliosphere, the interstellar medium, the Kuiper Belt, the circumsolar dust disk, and the evolution of our solar system. This session invites contributions on the groundbreaking science of interstellar probe exploration, instrumentation for relevant in-situ and remote measurements, and the relevant mission and spacecraft concepts.