With discoveries of the past (e.g., Mariner, Pioneers, Ulysses) and the present (e.g., Voyager, SOHO/SWAN, IBEX, New Horizons) heliospheric missions, the exploration of the heliosphere, its boundary regions, the outer reaches of our solar system, as well as the Very Local Interstellar Medium (VLISM) has profoundly changed the view of our space in the universe. The Interstellar Mapping and Acceleration Probe (IMAP) is a future space mission dedicated to study the interaction of the solar wind with the interstellar medium and the acceleration of energetic particles. These two topics are crucial for understanding the coupling between the inner and the outer heliosphere. The Interstellar Probe escaping beyond the solar-system boundaries with new measurements would be crucial to enable the new understanding and discoveries of the global heliosphere, the interstellar medium, the Kuiper Belt, the circumsolar dust disk, and the evolution of our solar system. This session focuses on advancing the understanding of the heliosphere and its interaction with VLISM as well as the groundbreaking science of interstellar exploration, instrumentation for relevant in-situ and remote measurements, and the relevant mission and spacecraft concepts.