Climate change is taking place at all levels of the atmosphere, from the surface to the edge of space. It is well-known that increasing greenhouse gas concentrations, in particular CO2, cause cooling and contraction throughout the middle and upper atmosphere. In the middle atmosphere, stratospheric ozone depletion and subsequent recovery play an important role as well, and interactions with circulation changes are still being disentangled. There are still considerable unknowns regarding long-term changes in atmospheric dynamics, including winds, tides, planetary waves, gravity waves, and large-scale residual circulations. These can also be related to considerable spatial variations in long-term trends in for example temperature or ionospheric quantities, as well as dependencies of trends on season and local time. In the ionosphere, additional spatial variations and seasonal/local time dependencies arise from long-term changes in the Earth’s magnetic field, which can also interact with variability and changes in atmospheric dynamics. Building a consistent pattern of long-term change across different atmospheric layers, regions, seasons and local times is therefore a fundamental challenge, which is important to address, given the connections with climate change near the surface and impacts of upper atmospheric changes on space operations and sustainability. This session welcomes studies that contribute to a more comprehensive understanding of all aspects of long-term changes in the stratosphere, mesosphere, thermosphere, and ionosphere, as well as their broader impacts, from surface weather to space operations.