Amid accelerating biodiversity loss and rising socio-environmental pressures in the Amazon, building effective socio-bioeconomic solutions requires collaborative structures that bridge science, innovation, local knowledge, and community engagement. This paper examines the contributions of nexBio Amazônia, a Brazil–Switzerland bilateral training program (2023–2025) designed for early-stage startups, researchers, innovation practitioners, and other stakeholders dedicated to biodiversity-oriented entrepreneurship. With its second edition now completed, the program offers timely insights into how structured capacity-building can foster inclusive, intersectoral collaboration for sustainable development.
Using a mixed-methods approach (participant observation, program evaluation data, alumni and local community and ERI actors interviews), we analyze how the program mobilizes community participation and cross-sector partnerships to strengthen science–innovation–action interfaces. Three findings stand out. First, it embeds co-design practices into its training model, enabling participants to refine problem/questions, evidence needs, and solution concepts together with Indigenous and traditional communities. This shifts community members from end-users or beneficiaries to active partners in shaping priorities and pathways.
Second, nexBio Amazônia supports reciprocal knowledge exchange, integrating scientific evidence with traditional and experiential insights to generate contextually relevant outputs such as productive inclusion, biodiversity-based value chains, and territorial development proposals. Its bilateral structure helps participants navigate common North–South asymmetries, fostering more ethical and balanced collaborations.
Third, the program enhances ecosystem connectivity by linking community actors with universities, incubators, policy institutions, and funding agencies, creating enabling conditions for sustained participation and post-program continuity.
The analysis also identifies key challenges: fragmented funding cycles that undermine long-term community partnerships, regulatory uncertainties affecting biodiversity-based ventures, and limited institutional mechanisms to maintain intersectoral collaboration once training ends. Looking forward, we argue for long-term funding commitments, improved alignment between innovation business strategies and territorial priorities, and dedicated structures to anchor community participation beyond project timelines.
Keywords: Amazon; socio-bioeconomy; biodiversity; intersectoral collaboration; bilateral training; co-design; traditional knowledge; sustainable entrepreneurship; science-innovation-action interface; long-term partnerships; North–South collaboration; innovation.