Effects of air pollution, urbanization and temperature on chronic kidney disease

The prevalence of chronic kidney disease in China is around 11%, which is a serious public health challenge. Air pollution and personal habits have been cited as major causes of chronic kidney disease, but a number of studies have suggested that urbanization and meteorological factors may also play a role. Therefore, this study established a longitudinal population cohort composed of 47,204 Chinese residents, combined with geographical means to obtain PM2.5 and temperature data, and used multiple regression model and random forest algorithm to explore the impact of air pollution, urbanization and temperature on chronic kidney disease. The results showed that the contribution of temperature, urbanization and PM2.5 to CKD was second only to individual factors such as age and BMI, and the contribution of temperature and urbanization to eGFR was higher than that of PM2.5. This provides a new way of thinking for the study of non-communicable diseases such as chronic kidney disease. With the acceleration of climate warming and urbanization, more attention should be paid to the impact of urbanization and temperature on diseases.