The first step from molecules to life: Formation of large random molecules acting as micro-environments
- Netherlands (smitra00@gmail.com)
The mathematician John von Neumann, through his work on universal constructors, discovered
a generalized version of the central dogma of molecular biology biology in the 1940s, long
before the biological version had been discovered. While his discovery played no role in the
development of molecular biology, we may benefit from a similar mathematical approach to find
clues on the origin of life. This then involves addressing those problems in the field that
do not depend on the details of organic chemistry. We can then consider a general set of
models that describe machines capable of self-maintenance and self-replication formulated in
terms of a set of building blocks and their interactions.
The analogue of the origin of life problem is then to explain how one can get to such
machines starting from a set of only building blocks. A fundamental obstacle one then faces
is the limit on the complexity of low fidelity replicating systems, preventing building
blocks from getting assembled randomly into low fidelity machines which can then improve due
to natural selection [1]. A generic way out of this problem is for the entire ecosystem of
machines to have been encapsulated in a micro-structure with fixed inner surface features
that would have boosted the fidelity [2]. Such micro-structures could have formed as a result
of the random assembly of building blocks, leading to so-called percolation clusters [2].
This then leads us to consider how in the real world a percolation process involving the
random assembly of organic molecules can be realized. A well studied process in the
literature is the assembly of organic compounds in ice grains due to UV radiation and heating
events [3,4,5]. This same process will also lead to the percolation process if it proceeds
for a sufficiently long period [2].
In this talk I will discuss the percolation process in more detail than has been done in [2],
explaining how it leads to the necessary symmetry breakings such as the origin of chiral
molecules needed to explain the origin of life.
[1] Eigen, M., 1971. Self-organization of matter and the evolution of biological
macromolecules. Naturwissenschaften 58, 465-523.
[2] Mitra, S., 2019. Percolation clusters of organics in interstellar ice grains as the
incubators of life, Progress in Biophysics and Molecular Biology 149, 33-38.
[3] Ciesla, F., and Sandford.,S., 2012. Organic Synthesis via Irradiation and Warming of Ice
Grains in the Solar Nebula. Science 336, 452-454.
[4] Muñoz Caro, G., et al., 2002. Amino acids from ultraviolet irradiation of interstellar ice
analogues. Nature 416, 403-406.
[5] Meinert, C,., et al., 2016. Ribose and related sugars from ultraviolet irradiation of
interstellar ice analogs. Science 352, 208-212.
How to cite: Mitra, S.: The first step from molecules to life: Formation of large random molecules acting as micro-environments, Europlanet Science Congress 2020, online, 21 September–9 Oct 2020, EPSC2020-785, https://doi.org/10.5194/epsc2020-785, 2020