Rights-based approaches are proving pivotal as we struggle with the challenges around biodiversity loss and ecosystem degradation. Human rights span a broad spectrum from individual and community-based rights to national and global human rights to healthy ecosystems, which includes access. Rights of Nature, implicit in many Indigenous communities, have seen growing recognition in recent decades and, in several instances, personhood of nature/parts thereof have been granted legal standing. This introduces a new dimension to management of anthropogenic activities. In this session, we examine potential synergies and trade-offs when aiming for a balance between human rights and nature’s rights as we strive towards more desirable futures. We focus on rights-based approaches in managing human-nature interactions, with a view to transforming nature-human inter-relations and coexistence, and as a means to better implement real ecosystem-based management.