Anthropogenic activities, climate change and poor water resources management lead to insufficient water quality, both biological and chemical, and results in one of the world’s most urgent human health issues. Waterbodies are key for waterborne diseases and water surface water network for spreading of contaminants and diseases. The global health burden could be reduced by improving water supply, sanitation and management of water resources but also by improved understanding of the role of hydrology in transport of pathogens. This scientific session aims to explore the interdisciplinary facets of water cycle and human health in broad sense. By bringing together experts from hydrology, environmental pollution, microbiology, ecology, epidemiology and public health, this session seeks to foster a dialogue to effectively study hydrological processes related to spreading and transmission of diseases and emergent contaminants. The oral part of the session is composed of solicited presentations followed by a panel discussion.